The Biotechnology Facility for International Space Station

The primary mission of the Cellular Biotechnology Program is to advance microgravity as a tool in basic and applied cell biology. The microgravity environment can be used to study fundamental principles of cell biology and to achieve specific applications such as tissue engineering. The Biotechnology Facility (BTF) will provide a state-of-the-art facility to perform cellular biotechnology research onboard the International Space Station (ISS). The BTF will support continuous operation, which will allow performance of long-duration experiments and will significantly increase the on-orbit science throughput. With the BTF, dedicated ground support, and a community of investigators, the goals of the Cellular Biotechnology Program at Johnson Space Center are to: Support approximately 400 typical investigator experiments during the nominal design life of BTF (10 years). Support a steady increase in investigations per year, starting with stationary bioreactor experiments and adding rotating bioreactor experiments at a later date. Support at least 80% of all new cellular biotechnology investigations selected through the NASA Research Announcement (NRA) process. Modular components - to allow sequential and continuous experiment operations without cross-contamination Increased cold storage capability (+4 C, -80 C, -180 C). Storage of frozen cell culture inoculum - to allow sequential investigations. Storage of post-experiment samples - for return of high quality samples. Increased number of cell cultures per investigation, with replicates - to provide sufficient number of samples for data analysis and publication of results in peer-reviewed scientific journals

Spacecraft Dormancy Autonomy Analysis for a Crewed Martian Mission

Current concepts of operations for human exploration of Mars center on the staged deployment of spacecraft, logistics, and crew. Though most studies focus on the needs for human occupation of the spacecraft and habitats, these resources will spend most of their lifetime unoccupied. As such, it is important to identify the operational state of the unoccupied spacecraft or habitat, as well as to design the systems to enable the appropriate level of autonomy. Key goals for this study include providing a realistic assessment of what "dormancy" entails for human spacecraft, exploring gaps in state-of-the-art for autonomy in human spacecraft design, providing recommendations for investments in autonomous systems technology development, and developing architectural requirements for spacecraft that must be autonomous during dormant operations. The mission that was chosen is based on a crewed mission to Mars. In particular, this study focuses on the time that the spacecraft that carried humans to Mars spends dormant in Martian orbit while the crew carries out a surface mission. Communications constraints are assumed to be severe, with limited bandwidth and limited ability to send commands and receive telemetry. The assumptions made as part of this mission have close parallels with mission scenarios envisioned for dormant cis-lunar habitats that are stepping-stones to Mars missions. As such, the data in this report is expected to be broadly applicable to all dormant deep space human spacecraft